Primary Mediastinal Choriocarcinoma in an Elderly Patient with Concurrent Goserelin-Treated Prostate Adenocarcinoma.
Rasmus RøgeCarsten SimonsenAstrid Christine PetersenPublished in: Case reports in pathology (2019)
Mediastinal pure choriocarcinomas are exceedingly rare representations of germ cell tumours and are associated with a poor prognosis. To date, fewer than 20 cases have been reported. This current report describes an elderly patient who developed a large rapidly growing mediastinal tumour. Unfortunately, the patient expired before a definitive diagnosis could be reached. An autopsy revealed that the histomorphological features of the tumour showed two distinct tumour cell populations (syncytio- and cytotrophoblasts), and the diagnosis of choriocarcinoma was made. Immunohistochemical analysis showed a characteristic staining pattern in agreement with published studies. Here, we report a case of primary mediastinal choriocarcinoma in an elderly male with concurrent metastasizing prostate adenocarcinoma treated with long-term goserelin deposits, which, as we speculate, could have induced the choriocarcinoma.
Keyphrases
- poor prognosis
- lymph node
- locally advanced
- prostate cancer
- case report
- middle aged
- ultrasound guided
- squamous cell carcinoma
- long non coding rna
- germ cell
- single cell
- community dwelling
- systematic review
- benign prostatic hyperplasia
- stem cells
- working memory
- mesenchymal stem cells
- rectal cancer
- bone marrow
- case control