Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1β on rheumatoid arthritis fibroblast-like synoviocytes.
Beatrice BergströmHans CarlstenAnna-Karin Hultgård EkwallPublished in: Arthritis research & therapy (2018)
Therapeutic concentrations of MTX abolish the effects of PDGF and IL-1β on tumor suppressor expression and inhibit mitogen-promoted FLS proliferation. These data demonstrate novel and important effects of MTX on pathogenic effector cells in the joint, which might involve epigenetic mechanisms.
Keyphrases
- growth factor
- rheumatoid arthritis
- induced apoptosis
- poor prognosis
- signaling pathway
- cell cycle arrest
- protein kinase
- dna methylation
- high dose
- gene expression
- disease activity
- electronic health record
- regulatory t cells
- dendritic cells
- nuclear factor
- vascular smooth muscle cells
- cell death
- ankylosing spondylitis
- toll like receptor
- interstitial lung disease
- systemic sclerosis
- pi k akt
- inflammatory response