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The shaky foundations of simulating single-cell RNA sequencing data.

Helena Lucia CrowellSarah X Morillo LeonardoCharlotte SonesonMark D Robinson
Published in: Genome biology (2023)
Our results suggest that most simulators are unable to accommodate complex designs without introducing artificial effects, they yield over-optimistic performance of integration and potentially unreliable ranking of clustering methods, and it is generally unknown which summaries are important to ensure effective simulation-based method comparisons.
Keyphrases
  • single cell
  • rna seq
  • high throughput
  • electronic health record
  • virtual reality
  • data analysis
  • deep learning