Myeloid leukemia-derived galectin-1 downregulates CAR expression to hinder cytotoxicity of CAR T cells.

Chuo LiShiyu ZuoLingling ShanHuifang HuangHaidong CuiXiaoming Feng

Published in: Journal of translational medicine (2024)

The discovery of the role of galectin-1 in cell surface CAR down-regulation provides important insights for developing strategies to restore anti-tumor functions.

Keyphrases

cell surface
acute myeloid leukemia
bone marrow
poor prognosis
small molecule
dendritic cells
high throughput
binding protein
immune response