DNA damage repair gene mutations and their association with tumor immune regulatory gene expression in muscle invasive bladder cancer subtypes.
Thiago VidottoSarah NersesianCharles GrahamD Robert SiemensMadhuri KotiPublished in: Journal for immunotherapy of cancer (2019)
Findings from our study provide compelling evidence for co-expression of multiple immune checkpoint genes including, PD-1, PD-L1, IDO1, TIGIT, TIM-3, TGFB1, LAG3, and others, that potentially contribute to compensatory immune evasion in bladder tumors. Our findings also emphasize the urgent need for biomarker discovery approaches that combine molecular subtype, DDR gene mutation status, tumor immune landscape classification, and immune checkpoint gene expression to increase the number of patients responding to immunotherapies.
Keyphrases
- gene expression
- dna damage
- end stage renal disease
- muscle invasive bladder cancer
- dna methylation
- newly diagnosed
- chronic kidney disease
- poor prognosis
- ejection fraction
- machine learning
- oxidative stress
- spinal cord injury
- high throughput
- peritoneal dialysis
- genome wide
- transcription factor
- patient reported outcomes
- long non coding rna
- single cell