Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood.

Mingfang XiongYanyu XiuJuan LongXiao ZhaoQianqian WangHaoyu YangHang YuLihong BianYan JuHongyu YinQingxiang HouFei LiangNan LiuFudong ChenRuiwen FanYuying SunYang Zeng

Published in: Stem cell research & therapy (2024)

The metabolic landscape of human HSPCs at three developmental stages (FL, UCB, and aBM), combined with proteomics and functional validations, substantially extends our understanding of HSC metabolic regulation. These findings provide valuable resources for understanding human HSC function and development during fetal and adult life.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
mass spectrometry
young adults
single cell