Liraglutide modulates morpho-functional and inflammatory gastrointestinal responses in rats.
Jhony Willams Gusmão-NascimentoDaniela Maione Nunes CruzLoyane Almeida GamaWellington David Luz AlvesMariana Pirani Rocha MachadoLuciana Aparecida CoráMadileine Francely AméricoPublished in: European journal of clinical investigation (2023)
Liraglutide reduced fat accumulation, improved metabolic parameters and downregulated levels of inflammatory signalling in duodenal tissue. Liraglutide at high doses controlled obesity-related outcomes, and such effects seemed to be driven by its action on glucagon-like peptide-1 receptors in the gastrointestinal tract slowing gastric motility.