Porcine epidemic diarrhea virus S1 protein is the critical inducer of apoptosis.
Yifeng ChenZhibang ZhangJie LiYueyi GaoLei ZhouXinna GeJun HanXin GuoHanchun YangPublished in: Virology journal (2018)
S1 Spike protein is one of the most critical functional proteins that contribute to cell apoptosis. Expression of S1 proteins of the coronavirus tested in this study could all induce cell apoptosis suggesting S1 maybe is an effective inducer in Coronavirus-induced cell apoptosis and targeting S1 protein expression probably is a promising strategy to inhibit coronavirus infection and thus mediated apoptosis on host cells.
Keyphrases
- sars cov
- cell cycle arrest
- cell proliferation
- induced apoptosis
- binding protein
- respiratory syndrome coronavirus
- endoplasmic reticulum stress
- cell death
- poor prognosis
- protein protein
- oxidative stress
- pi k akt
- amino acid
- high glucose
- diabetic rats
- cancer therapy
- small molecule
- signaling pathway
- long non coding rna
- stress induced
- disease virus