Metal-Containing Poly(ionic liquid) Membranes for Antibacterial Applications.
Zhiqiang ZhengJiangna GuoHailei MaoQiming XuJing QinFeng YanPublished in: ACS biomaterials science & engineering (2017)
Imidazolium-type metal-containing ionic liquid (IL) monomers and their corresponding poly(ionic liquid) (PIL) membranes coordinated with CuCl2 (PILM-Cu), FeCl3 (PILM-Fe), or ZnCl2 (PILM-Zn) were synthesized. The effect of metal ions on the antimicrobial activities against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) was investigated. Compared with pristine PILM-Br membrane, PILM-Cu, PILM-Fe, and PILM-Zn membranes exhibit enhanced antibacterial activities due to the attributes of both imidazolium cations and metal-containing anions. Furthermore, all of the metal-containing PIL membranes present low hemolysis toward human red blood cell and high long-term antibacterial stability, even after immersion in water for 90 days, demonstrating clinical feasibility in topical applications.
Keyphrases
- ionic liquid
- escherichia coli
- staphylococcus aureus
- red blood cell
- room temperature
- endothelial cells
- heavy metals
- silver nanoparticles
- wound healing
- biofilm formation
- quantum dots
- pseudomonas aeruginosa
- anti inflammatory
- risk assessment
- cystic fibrosis
- high resolution
- essential oil
- klebsiella pneumoniae
- pluripotent stem cells
- candida albicans