Optogenetic intervention of seizures improves spatial memory in a mouse model of chronic temporal lobe epilepsy.

Hannah K KimTilo GschwindTheresa M NguyenAnh D BuiSylwia FelongKristen AmpigDavid SuhAnnie V CierniaMarcelo A WoodIvan Soltesz

Published in: Epilepsia (2020)

Many currently available treatments for epilepsy target seizures but not the associated comorbidities, therefore there is a need to investigate new potential therapies that may be able to improve both seizure burden and associated comorbidities of epilepsy. In this study, we showed that optogenetic intervention may be able to both shorten seizure duration and improve cognitive outcomes of spatial memory.

Keyphrases

temporal lobe epilepsy
randomized controlled trial
mouse model
working memory
type diabetes
risk factors
metabolic syndrome