Reductive Deuteration of Acyl Chlorides for the Synthesis of α , α -Dideuterio Alcohols Using SmI 2 and D 2 O.

The synthesis of α , α -dideuterio alcohols has been achieved via single electron transfer reductive deuteration of acyl chlorides using SmI 2 and D 2 O. This method is distinguished by its remarkable functional group tolerance and exquisite deuterium incorporation, which has also been applied to the synthesis of valuable deuterated agrochemicals and their building blocks.