Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes.
Jing XuCongshan JiangYongsong CaiYuanxu GuoXipeng WangJiaxiang ZhangJiawen XuKe XuWenhua ZhuSi WangFujun ZhangManman GengYan HanQilan NingPeng XuLiesu MengShemin LuPublished in: Arthritis research & therapy (2020)
Activated NF-κB pathway upregulates SLC7A5, which enhances the mTOR-P70S6K activity and MMP3 and MMP13 expression in RA FLS.
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