Establishment of gene-edited pigs expressing human blood-coagulation factor VII and albumin for bioartificial liver use.
Li LiHongyi MengQingjian ZouJianmin ZhangLei CaiBin YangJun WengLiangxue LaiHuaqiang YangYi GaoPublished in: Journal of gastroenterology and hepatology (2019)
The gene-edited pigs expressing hF7 and hALB in the liver were generated successfully. We anticipate that our pigs could provide an alternative cell source for BALs as a promising treatment for patients with acute liver failure.
Keyphrases
- liver failure
- crispr cas
- copy number
- hepatitis b virus
- endothelial cells
- genome wide
- genome wide identification
- single cell
- stem cells
- gene expression
- heart failure
- induced pluripotent stem cells
- dna methylation
- mesenchymal stem cells
- combination therapy
- pluripotent stem cells
- bone marrow
- transcription factor
- genome wide analysis
- atrial fibrillation
- wild type