Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression.

Po-Chun ChenChih-Hsin TangLiang-Wei LinChun-Hao TsaiCheng-Ying ChuTien-Huang LinYuan-Li Huang

Published in: Journal of hematology & oncology (2017)

Taken together, our results indicate that TSP-2 enhances the migration of PCa cells by increasing MMP-2 expression through down-regulation of miR-376c expression. Therefore, TSP-2 may represent a promising new target for treating PCa.

Keyphrases

poor prognosis
prostate cancer
long non coding rna
cell proliferation
induced apoptosis
binding protein
long noncoding rna
radical prostatectomy
cell cycle arrest
oxidative stress
bone loss