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Localization of EGFR Mutations in Non-small-cell Lung Cancer Tissues Using Mutation-specific PNA-DNA Probes.
Hajime Shigeto
Haruo Miyata
Tadashi Ashizawa
Akira Iizuka
Yasufumi Kikuchi
Chikako Hozumi
Chie Maeda
Ken Yamaguchi
Shohei Yamamura
Yasuto Akiyama
Published in:
Cancer genomics & proteomics (2023)
PNA-DNA probes specific for EGFR mutations might be useful tools to detect heterogeneous mutant EGFR expression in cancer tissues and efficiently evaluate the effect of EGFR signaling inhibitors on tissues of EGFR-mutant cancer.
Keyphrases
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small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
nucleic acid
single molecule
papillary thyroid
gene expression
small molecule
circulating tumor
poor prognosis
squamous cell
cell free
living cells
squamous cell carcinoma
lymph node metastasis
childhood cancer
wild type