Antibody Response to HML-2 May Be Protective in Amyotrophic Lateral Sclerosis.
Marta Garcia-MontojoElena Rita SimulaSaeed FathiCynthia McMahanAnubrata GhosalJames D BerryMerit E CudkowiczAbdel ElkahlounKory JohnsonGina NoratoPeter JensenTony JamesLeonardo A SechiAvindra NathPublished in: Annals of neurology (2022)
There is a differential antibody response against specific epitopes of HML-2 env in ALS and controls, suggesting epitope spreading, likely due to persistent antigenic exposure following reactivation of the viral genes. Low levels of antibodies to HML-2 env in ALS are associated with poor prognosis and decreased survival probability. ANN NEUROL 2022;92:782-792.