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Lack of Histological and Molecular Signature Response to Tocilizumab in Kidney Transplants with Chronic Active Antibody Mediated Rejection: A Case Series.

Dhiren KumarIdris YakubuFrough SafaviMarlon LevyIrfan MoinuddinPamela KimballLayla KamalAnne KingDavis MasseyPhilip HalloranGaurav Gupta
Published in: Kidney360 (2020)
In this early experience, we report a lack of efficacy and toxicity with the use of TCZ for caAbMR. Prospective clinical trials are needed to clarify the role of IL-6 blockade and the possibility of increased incidence of infections in patients with caAbMR who are treated with TCZ.
Keyphrases
  • clinical trial
  • rheumatoid arthritis
  • risk factors
  • oxidative stress
  • rheumatoid arthritis patients
  • phase ii
  • single molecule
  • newly diagnosed