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Increased Levels of Phosphorylated-P38α Induce WNT/β-Catenin and NGF/P75NTR/TrkA Pathways Disruption and SN56 Cell Death following Single and Repeated Chlorpyrifos Treatment.

Paula MoyanoAndrea FloresMaría de la Cabeza FernándezJimena GarcíaJavier SanjuanJosé Carlos PlazaJavier Del Pino
Published in: Foods (Basel, Switzerland) (2024)
Chlorpyrifos (CPF) biocide, exposure to which is mainly produced in the human population through diet, induces several neurotoxic effects. CPF single and repeated exposure induces memory and learning disorders, although the mechanisms that produce these outcomes are complex and not well understood. CPF treatment (single and repeated) of cholinergic septal SN56 cells induced an increase in phosphorylated-P38α levels that led to WNT/β-Catenin and NGF/P75 NTR /TrkA pathways disruption and cell death. These results provide new knowledge on the mechanisms that mediate CPF basal forebrain cholinergic neuronal loss induced by CPF single and repeated exposure and can help unravel the way through which this compound produces cognitive decline and develop efficient treatments against these effects.
Keyphrases
  • cell death
  • genome editing
  • cognitive decline
  • cell proliferation
  • crispr cas
  • cell cycle arrest
  • endothelial cells
  • stem cells
  • healthcare
  • induced apoptosis
  • high glucose
  • metabolic syndrome
  • brain injury
  • stress induced