Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens.
Verónica MixãoJuan Carlos Nunez-RodriguezValentina Del OlmoEwa KsiezopolskaEster SausTeun BoekhoutAttila GacserToni GabaldonPublished in: BMC biology (2023)
Our results suggest that genetic drift is the prevailing force shaping LOH patterns in these hybrid genomes. Moreover, the observed LOH patterns suggest that these are likely not the result of continuous accumulation of sporadic events-as expected by mitotic repair of rare chromosomal breaks-but rather of acute episodes involving many LOH events in a short period of time.
Keyphrases
- liver failure
- late onset
- cell cycle
- respiratory failure
- staphylococcus aureus
- pseudomonas aeruginosa
- single molecule
- candida albicans
- gene expression
- gram negative
- intensive care unit
- dna methylation
- drug induced
- biofilm formation
- cystic fibrosis
- extracorporeal membrane oxygenation
- mechanical ventilation
- antimicrobial resistance
- cell wall