The MIND diet, brain transcriptomic alterations, and dementia.
A Heather EliassenAna W CapuanoPuja AgarwalZoe ArvanitakisYanling WangPhilip L De JagerJulie A SchneiderShinya TasakiKatia de Paiva LopesFrank B HuDavid A BennettLiming LiangFrancine GrodsteinPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Why healthy dietary patterns are associated with lower dementia risk are unknown. We integrated dietary, brain transcriptomic, and cognitive data in older adults. Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet intake is correlated with a specific brain transcriptomic profile. This brain transcriptomic profile score is associated with better cognitive health. More data are needed to elucidate the causality and functionality of identified genes.
Keyphrases
- white matter
- resting state
- single cell
- physical activity
- rna seq
- mild cognitive impairment
- blood pressure
- healthcare
- cerebral ischemia
- randomized controlled trial
- public health
- electronic health record
- cognitive impairment
- mental health
- big data
- genome wide
- gene expression
- multiple sclerosis
- dna methylation
- deep learning
- blood brain barrier
- social media
- transcription factor
- subarachnoid hemorrhage
- health promotion
- genome wide analysis
- breast cancer risk