Association of CD200 expression in paternal lymphocytes with female Th1/Th2 balance and pregnancy establishment at immunotherapy of recurrent spontaneous abortion.

Alla ArefievaMarina NikolaevaElena StepanovaLubov KrechetovaElena GolubevaNana TetruashviliGennady Sukhikh

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)

Elevated CD200 expression on allogeneic lymphocytes most likely suppresses the pro-inflammatory Th1-type immunity needed for successful embryo implantation. Therefore, a personalized approach of LIT should be applied to avoid negative effects of such immunomodulation on pregnancy establishment.

Keyphrases

poor prognosis
pregnancy outcomes
preterm birth
peripheral blood
stem cell transplantation
bone marrow
binding protein
signaling pathway
nk cells
long non coding rna
pregnant women