TERT promoter mutations increase tumor aggressiveness by altering TERT mRNA splicing in papillary thyroid carcinoma.
Ayaka SakoMichiko MatsuseVladimir A SaenkoAya TanakaRyota OtsuboMichi MoritaSayaka KubaEijun NishiharaKeiji SuzukiTomoo OgiAtsushi KawakamiNorisato MitsutakePublished in: The Journal of clinical endocrinology and metabolism (2024)
These results provide evidence that the TERT-p mutations alter the expression of different TERT splice variants, which, in turn, associates with different tumor aggressiveness.