Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.

Negin HollandP Simon JonesGeorge SavulichJulie K WigginsYoung T HongTim D FryerRoido Manavaki Selena Milicevic SephtonIstvan BorosMaura Malpetti Frank H Hezemans Franklin I AigbirhioJonathan P ColesJohn Tiernan O'Brien James Benedict Rowe

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

We confirm severe synaptic loss in PSP and CBD in proportion to disease severity, providing critical insight into the pathophysiology of primary degenerative tauopathies. [11 C]UCB-J may facilitate treatment strategies for disease-modification, synaptic maintenance, or restoration. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

positron emission tomography
computed tomography
prefrontal cortex
pet ct
pet imaging
randomized controlled trial