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Copper(I) Complex Mediated Nitric Oxide Reductive Coupling: Ligand Hydrogen Bonding Derived Proton Transfer Promotes N2O(g) Release.

Gayan B WijeratneMayukh BhadraMaxime A SieglerKenneth D Karlin
Published in: Journal of the American Chemical Society (2019)
A cuprous chelate bearing a secondary sphere hydrogen bonding functionality, [(PV-tmpa)CuI]+, transforms •NO(g) to N2O(g) in high-yields in methanol. Ligand derived proton transfer facilitates N-O bond cleavage of a putative hyponitrite intermediate releasing N2O(g), underscoring the crucial balance between H-bonding capabilities and acidities in (bio)chemical •NO(g) coupling systems.
Keyphrases
  • electron transfer
  • nitric oxide
  • room temperature
  • nitric oxide synthase
  • dna binding