METTL3-Mediated m6A Modification Controls Splicing Factor Abundance and Contributes to Aggressive CLL.

Yiming Wu Meiling Jin Mike Minh Fernandez Kevyn Lopez Hart Aijun Liao Xinzhou Ge Stacey M Fernandes Tinisha McDonald Zhenhua Chen Daniel Röth Lucy Y Ghoda Guido Marcucci Markus Kalkum Raju K Pillai Alexey V Danilov Jingyi Jessica Li Jianjun Chen Jennifer R Brown Steven T Rosen Tanya Siddiqi Lili Wang

Published in: Blood cancer discovery (2023)

METTL3 controls widespread splicing factor abundance via translational control of m6A-modified mRNA, contributes to RNA splicing dysregulation and disease progression in CLL, and serves as a potential therapeutic target in aggressive CLL. See related commentary by Janin and Esteller.

Keyphrases

chronic lymphocytic leukemia
antibiotic resistance genes

microbial community
wastewater treatment

human health

climate change