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METTL3-Mediated m6A Modification Controls Splicing Factor Abundance and Contributes to Aggressive CLL.

Yiming WuMeiling JinMike Minh FernandezKevyn Lopez HartAijun LiaoXinzhou GeStacey M FernandesTinisha McDonaldZhenhua ChenDaniel RöthLucy Y GhodaGuido MarcucciMarkus KalkumRaju K PillaiAlexey V DanilovJingyi Jessica LiJianjun ChenJennifer R BrownSteven T RosenTanya SiddiqiLili Wang
Published in: Blood cancer discovery (2023)
METTL3 controls widespread splicing factor abundance via translational control of m6A-modified mRNA, contributes to RNA splicing dysregulation and disease progression in CLL, and serves as a potential therapeutic target in aggressive CLL. See related commentary by Janin and Esteller.
Keyphrases
  • chronic lymphocytic leukemia
  • antibiotic resistance genes
  • microbial community
  • wastewater treatment
  • human health
  • climate change