Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice.
Karen A FortnerLuz P BlancoIwona BuskiewiczNick HuangPamela C GibsonDeborah L CookHege L PedersenPeter S T YuenMichael P MurphyAndras PerlMariana J KaplanRalph C BuddPublished in: Lupus science & medicine (2020)
These findings reveal the potential utility of targeting mROS in addition to traditional immunosuppressive therapy for lupus.