Near-Infrared Light-Driven Nanoparticles for Cancer Photoimmunotherapy by Synergizing Immune Cell Death and Epigenetic Regulation.
Huizhe WangXiaohui XiongJiaqi ZhangMeicen WuYinhui GuYanli ChenYueQing GuPeng WangPublished in: Small (Weinheim an der Bergstrasse, Germany) (2023)
Histone deacetylases (HDACs) are a class of epigenetic enzymes that are closely related to tumorigenesis and suppress the expression of tumor suppressor genes. Whereas the HDACs inhibitors can release DNA into the cytoplasm and trigger innate immunity. However, the high density of chromatin limits DNA damage and release. In this study, suitable nanosized CycNHOH NPs (150 nm) and CypNHOH NPs (85 nm) efficiently accumulate at the tumor site due to the enhanced permeability and retention (EPR) effect. In addition, robust single-linear oxygen generation and good photothermal conversion efficiency under NIR laser irradiation accelerated the DNA damage process. By effectively initiating immune cell death, CypNHOH NPs activated both innate and adaptive immunity by maturing dendritic cells, infiltrating tumors with natural killer cells, and activating cytotoxic T lymphocytes, which offer a fresh perspective for the development of photo-immunotherapy.
Keyphrases
- dna damage
- cell death
- photodynamic therapy
- high density
- dendritic cells
- natural killer cells
- immune response
- dna methylation
- dna repair
- oxidative stress
- poor prognosis
- genome wide
- cell cycle arrest
- oxide nanoparticles
- gene expression
- papillary thyroid
- signaling pathway
- circulating tumor
- drug release
- fluorescence imaging
- endothelial cells
- cell free
- regulatory t cells
- squamous cell carcinoma
- squamous cell
- radiation therapy
- cancer therapy
- fluorescent probe
- high resolution
- bioinformatics analysis
- genome wide identification