High-volume hemodiafiltration decreases the pre-dialysis concentrations of indoxyl sulfate and p-cresyl sulfate compared to hemodialysis: a post-hoc analysis from the HDFit randomized controlled trial.

Jordana D LimaMurilo GuedesSilvia D RodriguesAna Clara S FlóridoAndrea N Moreno-AmaralAna Beatriz BarraMaria Eugênia CanzianiAmérico Cuvello-NetoCarlos Eduardo Poli-de-FigueiredoRoberto Pecoits-FilhoLia Sumie Nakao

Published in: Journal of nephrology (2022)

These exploratory findings suggest that hemodiafiltration is more effective in reducing indoxyl sulfate as compared to standard high-flux hemodialysis, and also that this effect was extended to p-cresyl sulfate in patients achieving higher convective volumes.

Keyphrases

end stage renal disease
chronic kidney disease
peritoneal dialysis
randomized controlled trial
newly diagnosed
study protocol
ejection fraction
systematic review