γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential.
Maria Alvarado KristenssonPublished in: Signal transduction and targeted therapy (2018)
Knowledge of γ-tubulin is increasing with regard to the cellular functions of this protein beyond its participation in microtubule nucleation. γ-Tubulin expression is altered in various malignancies, and changes in the TUBG1 gene have been found in patients suffering from brain malformations. This review recapitulates the known functions of γ-tubulin in cellular homeostasis and discusses the possible influence of the protein on disease development and cancer.
Keyphrases
- end stage renal disease
- ejection fraction
- binding protein
- chronic kidney disease
- poor prognosis
- newly diagnosed
- healthcare
- protein protein
- peritoneal dialysis
- prognostic factors
- physical activity
- amino acid
- papillary thyroid
- white matter
- squamous cell carcinoma
- copy number
- multiple sclerosis
- resting state
- dna methylation
- squamous cell
- small molecule
- transcription factor
- genome wide identification