Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis.

Hongjuan YouDongchen YuanYanwei BiNing ZhangQi LiTao TuXiao WeiQi LianTong YuDelong KongXiaoying YangXiangye LiuXiaomei LiuFanyun KongKuiyang ZhengRen-Xian Tang

Published in: Cell communication and signaling : CCS (2021)

Taken together, these findings demonstrate that, dependent on LASP1, vimentin is crucial for HBX-mediated EMT and hepatocarcinogenesis, and may serve as a potential target for HBV-related HCC treatment. Video abstract.

Keyphrases

hepatitis b virus
epithelial mesenchymal transition
liver failure
binding protein
poor prognosis
protein protein
transforming growth factor
signaling pathway
amino acid
risk assessment