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Albumin versus balanced crystalloid for resuscitation in the treatment of sepsis: A protocol for a randomised controlled feasibility study, "ABC-Sepsis".

John CafferkeyAndrew FergusonJulia GrahamslawKatherine OateyJohn NorrieNazir I LoneTimothy WalshDaniel HornerAndy AppelboamPeter HallRichard SkipworthDerek BellKevin RooneyManu Shankar-HariAlasdair CorfieldAlasdair James Gray
Published in: Journal of the Intensive Care Society (2022)
This trial aims to determine the feasibility of conducting a trial to address the current uncertainty around optimal fluid resuscitation of patients with suspected sepsis. Understanding the feasibility of delivering a definitive study will be dependent on how the study team are able to negotiate clinician choice, Emergency Department pressures and participant acceptability, as well as whether any clinical signal of benefit is detected.
Keyphrases
  • septic shock
  • emergency department
  • study protocol
  • acute kidney injury
  • intensive care unit
  • cardiac arrest
  • randomized controlled trial
  • clinical trial
  • phase iii
  • squamous cell carcinoma
  • open label
  • smoking cessation