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Metagenomic sequencing of the skin microbiota of the scalp predicting the risk of surgical site infections following surgery of traumatic brain injury in sub-Saharan Africa.

Hervé Monka LekuyaDavid Patrick KateeteGeofrey OlwenyEdgar KigoziLarrey Kasereka KamabuSafari Paterne MudekerezaRose NantambiRonald MbiineFredrick MakumbiStephen CoseJelle VandersteeneEdward BaertJean-Pierre Okito KalalaMoses Galukande
Published in: PloS one (2024)
Metagenomic sequencing analysis uncovered several baseline findings and trends regarding the skin microbiome's relationship with SSI risk. There is an association between scalp microbiota composition (abundancy and diversity) and SSI occurrence following TBI surgery in SSA. We hypothesize under reserve that the scalp microbiota dysbiosis could potentially be an independent predictor of the occurrence of SSI; we advocate for further studies with larger cohorts.
Keyphrases
  • surgical site infection
  • traumatic brain injury
  • risk assessment
  • single cell
  • soft tissue
  • antibiotic resistance genes
  • wound healing
  • minimally invasive
  • case control
  • wastewater treatment
  • mild traumatic brain injury