KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma: A systematic review.

Marcos Ezequiel da Silva Santos Anna Karolina de Carvalho Abreu Fábio Willian Martins da Silva Elaine Barros Ferreira Paula Elaine Diniz Dos Reis Doralina do Amaral Rabello Ramos

Published in: Head & neck (2023)

KMT2C and KMT2D genes seem to have tumor suppressor activities, with involvement of cell cycle inhibitors, regulating different pathways that can lead to tumor progression, disease aggressiveness, and DNA damage accumulation.

Keyphrases

cell cycle
dna damage
cell proliferation
acute myeloid leukemia
oxidative stress
poor prognosis
genome wide
dna repair
gene expression
dna methylation
genome wide identification
small molecule
protein protein
bioinformatics analysis
genome wide analysis