Punicalagin reduces H2O2-induced cytotoxicity and apoptosis in PC12 cells by modulating the levels of reactive oxygen species.
Maria Elisabetta ClementiGiovambattista PaniBeatrice SampaoleseGiuseppe TringaliPublished in: Nutritional neuroscience (2017)
Results of the present study demonstrated a neuroprotective effect of punicalagin on H2O2-induced PC12 cell death, including mitochondria damage and expression of apoptotic gene Bax; therefore we hypothesize a possible prevent role for this molecule in neurodegenerative diseases related to oxidative stress.
Keyphrases
- cell death
- oxidative stress
- diabetic rats
- reactive oxygen species
- cell cycle arrest
- high glucose
- induced apoptosis
- poor prognosis
- drug induced
- endoplasmic reticulum stress
- dna damage
- ischemia reperfusion injury
- copy number
- blood brain barrier
- binding protein
- heat shock
- anti inflammatory
- cerebral ischemia
- genome wide identification
- heat stress