Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis.

Xuewei YinBin LiuHuixia WeiShanshan WuLijie GuoFuru XuTingTing LiuHongsheng BiDadong Guo

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)

The activation of the Notch signaling pathway can regulate Th17 and Treg cell differentiation, disrupt the CD4+/CD8+ and Th17/Treg balance, and aggravate the severity of EAU; inactivation of the Notch signaling pathway contributes to the CD4+/CD8+ and Th17/Treg balance in EAU rats. Our findings highlighted that the dynamic change in the CD4+/CD8+ and Th17/Treg ratio was consistent with the expression trend of Notch signaling in EAU rats, suggesting that Notch signaling may be a potentially important therapeutic target in clinical practice.

Keyphrases

signaling pathway
pi k akt
cell proliferation
clinical practice
epithelial mesenchymal transition
poor prognosis
induced apoptosis
multiple sclerosis
systemic lupus erythematosus
ankylosing spondylitis
rheumatoid arthritis
endoplasmic reticulum stress
disease activity