Resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation.
Weiguo XieXiaohu GeLing LiAthena YaoXiaoyan WangMin LiXiang GongZhigang ChuZhe LuXiaodong HuangYun JiaoYifei WangMeifang XiaoHaijia ChenWei XiangPaul YaoPublished in: Molecular autism (2018)
We conclude that resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation. Our data suggest that prenatal progestin exposure is a strong risk factor for autism-like behavior. Many potential clinical progestin applications, including oral contraceptive pills, preterm birth drugs, and progestin-contaminated drinking water or seafood, may be risk factors for ASD. In addition, RSV may be a good candidate for clinically rescuing or preventing ASD symptoms in humans, while high doses of resveratrol used in the animals may be a potential limitation for human application.
Keyphrases
- autism spectrum disorder
- drinking water
- intellectual disability
- preterm birth
- pregnant women
- high glucose
- endothelial cells
- attention deficit hyperactivity disorder
- diabetic rats
- health risk assessment
- drug induced
- health risk
- heavy metals
- low birth weight
- mouse model
- gestational age
- endoplasmic reticulum
- breast cancer cells
- physical activity
- human health
- electronic health record
- risk assessment
- deep learning
- sleep quality
- induced pluripotent stem cells
- respiratory tract
- pluripotent stem cells