Metastatic lymph node targeted CTLA4 blockade: a potent intervention for local and distant metastases with minimal ICI-induced pneumonia.

Radhika MishraAriunbuyan SukhbaatarShiro MoriTetsuya Kodama

Published in: Journal of experimental & clinical cancer research : CR (2023)

Intranodal delivery of immune checkpoint inhibitors to metastatic LN can potentiate therapeutic response while minimizing irAEs stemming from systemic lowering of immune activation threshold.

Keyphrases

lymph node
squamous cell carcinoma
small cell lung cancer
randomized controlled trial
neoadjuvant chemotherapy
high glucose
diabetic rats
drug induced
cancer therapy
oxidative stress
drug delivery
anti inflammatory
radiation therapy
rectal cancer
acute respiratory distress syndrome
endothelial cells