Tuberculosis Disease in Immunocompromised Children and Adolescents: A Pediatric Tuberculosis Network European Trials Group Multicenter Case-control Study.
Paula Rodríguez-MolinoMarc TebrueggeAntoni Noguera-JulianOlaf NethKaty FidlerFolke BrinkmannTalia SainzInga IvaskevicieneNicole RitzMaria Joao BritoTiago Milheiro SilvaVira ChechenievaMaryna SerdiukLaura LancellaCristina RussoAleix Soler-GarcíaMaria Luisa NavarroRenate KruegerCornelia Feiterna-SperlingAnna StarshinovaAntonina HitevaAnna HoffmannPaulius KalibatasAndrea Lo VecchioSara Maria ScaranoMatilde BustilloDaniel Blázquez GameroMaría EspiauDaniele Antonio PizzutoLola FalcónLouise TurnbullElena ColinoSantiago RuedaCharlotte BuxbaumBegoña CarazoCristina AlvarezMarta DapenaAnabel PiquerasSvetlana VelizarovaIveta OzereFlorian GötzingerMarta ParejaMaria Isabel Garrote LlanosBeatriz SotoSonia Rodríguez MartínJose Javier KortaBeatriz Pérez-GorrichoMercedes HerranzÁngel Hernández-BartoloméMariana Díaz-AlmirónMalte Kohns VasconcelosLaura Ferreras-AntolínBegoña Santiago-GarcíaPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Children with IC and TB in Europe have increased rates of nonrespiratory TB, severe disease, and long-term sequelae. Immune-based TB tests have poor sensitivity in those children. Future research should focus on developing improved immunological TB tests that perform better in patients with IC, and determining the reasons for the increased risk of long-term sequelae, with the aim to design preventive management strategies.