DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status.

Philipp JurmeisterKarsten WeberSonia VillegasThomas KarnMichael UntchAnne ThiemeVolkmar MüllerEliane TaubePeter FaschingWolfgang D SchmittFrederik MarméElmar StickelerBruno V SinnPaul JankChristian SchemFrederick KlauschenMarion van MackelenberghCarsten DenkertSibylle LoiblDavid Capper

Published in: Clinical epigenetics (2021)

We here demonstrate that LowHR breast cancer comprises two epigenetically distinct groups. Our data strongly suggest that LowHR TNBC-like samples are molecularly, histologically and clinically closely related to TNBC, while LowHR HRpos-like specimens are closely related to hormone receptor positive tumors.

Keyphrases

dna methylation
genome wide
poor prognosis
gene expression
single cell
young adults
deep learning