The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer.
Samer Al-SaadElin RichardsenThomas K KilvaerTom DonnemSigve AndersenMehrdad KhanehkenariRoy M BremnesLill-Tove BusundPublished in: PloS one (2017)
MET protein expression provides superior prognostic information compared with SISH. Polysomy of chromosome 7 is an independent negative prognostic factor in NSCLC patients. This finding has an important implication while examining genes located on chromosome 7 by means of SISH. High IGF1R gene copy number to chromosome 15 count ratio is an independent predictor of inferior survival in male patients with primary NSCLC.
Keyphrases
- copy number
- prognostic factors
- mitochondrial dna
- genome wide
- small cell lung cancer
- tyrosine kinase
- binding protein
- end stage renal disease
- dna methylation
- pi k akt
- ejection fraction
- advanced non small cell lung cancer
- poor prognosis
- epidermal growth factor receptor
- chronic kidney disease
- newly diagnosed
- growth hormone
- healthcare
- free survival
- brain metastases
- peripheral blood
- long non coding rna
- social media