High-Resolution Plasma Metabolomics Identifies Alterations in Fatty Acid, Energy, and Micronutrient Metabolism in Adults across the Leprosy Spectrum.
Jessica K FairleyJosé A FerreiraLucia A O FragaSandra LyonThales M Valadão CardosoVictor Campos BosonAna Carolina Madureira NunesEloisa H Medeiros CinhaLorena B P de OliveiraErica B MaguetaPedro H F MarçalAlexandre C BrancoMaria Aparecida F GrossiDean P JonesThomas R ZieglerJeffrey M CollinsPublished in: The Journal of infectious diseases (2023)
Metabolites associated with several nutrient-related metabolic pathways appeared differentially regulated in leprosy, especially MB vs PB. This pilot study demonstrates the metabolic interdependency of these pathways, which may play a role in the pathophysiology of disease.