High-Resolution Plasma Metabolomics Identifies Alterations in Fatty Acid, Energy, and Micronutrient Metabolism in Adults across the Leprosy Spectrum.

Jessica K FairleyJosé A FerreiraLucia A O FragaSandra LyonThales M Valadão CardosoVictor Campos BosonAna Carolina Madureira NunesEloisa H Medeiros CinhaLorena B P de OliveiraErica B MaguetaPedro H F MarçalAlexandre C BrancoMaria Aparecida F GrossiDean P JonesThomas R ZieglerJeffrey M Collins

Published in: The Journal of infectious diseases (2023)

Metabolites associated with several nutrient-related metabolic pathways appeared differentially regulated in leprosy, especially MB vs PB. This pilot study demonstrates the metabolic interdependency of these pathways, which may play a role in the pathophysiology of disease.

Keyphrases

high resolution
fatty acid
mass spectrometry
heavy metals
transcription factor
genome wide
gene expression
liquid chromatography
tandem mass spectrometry
high speed