Login / Signup

Mitochondrial respiratory chain and Krebs cycle enzyme function in human donor livers subjected to end-ischaemic hypothermic machine perfusion.

Hamid AbudhaiseJan-Willem TaanmanPeter DeMuylderBarry FullerBrian R Davidson
Published in: PloS one (2021)
Actively oxygenated and air-equilibrated end-ischaemic HMP did not induce oxidative damage of aconitase, and respiratory chain complexes remained intact. Mitochondria likely respond to variable perfusate oxygen levels by adapting their respiratory function during end-ischaemic HMP. Complex II-III activities should be further investigated as viability biomarkers.
Keyphrases
  • endothelial cells
  • respiratory tract
  • cell death
  • deep learning
  • mass spectrometry
  • pluripotent stem cells