Expression of ApoA5 and its function in the right ventricular failing and remodeling secondary to pulmonary hypertension.
Jingyuan ChenJun LuoXiaojie YangMinzhi OuyangTengteng ZhuYuanchang LiPeng LuoYusi ChenZilu LiJiang LiPublished in: Journal of cellular physiology (2020)
Right heart failure and right ventricular (RV) remodeling were the main reason for mortality of pulmonary hypertension (PH) patients. Apolipoprotein AV (ApoA5) is a key regulator of plasma triglyceride and have multifunction in several target organs. We detected decreased ApoA5 in serum of patients with PH and both in serum and RV of monocrotaline-induced PH model. Exogenously, overexpression ApoA5 by adenovirus showed protective effects on RV failure and RV fibrosis secondary to PH. In addition, in vitro experiments showed ApoA5 attenuated the activation of fibroblast induced by transforming growth factor β1 and synthesis and secretion of extracellular matrix by inhibiting focal adhesion kinase-c-Jun N-terminal kinase-Smad3 pathway. Finally, we suggest that ApoA5 may potentially be a pivotal target for RV failure and fibrosis secondary of PH.
Keyphrases
- mycobacterium tuberculosis
- pulmonary hypertension
- transforming growth factor
- extracellular matrix
- heart failure
- pulmonary arterial hypertension
- epithelial mesenchymal transition
- end stage renal disease
- pulmonary artery
- chronic kidney disease
- ejection fraction
- newly diagnosed
- transcription factor
- poor prognosis
- prognostic factors
- peritoneal dialysis
- risk factors
- signaling pathway
- protein kinase
- long non coding rna
- candida albicans