Mutation as a Toxicological Endpoint for Regulatory Decision-Making.
Robert H HeflichGeorge E JohnsonAndreas ZellerFrancesco MarchettiGeorge R DouglasKristine L WittB Bhaskar GollapudiPaul A WhitePublished in: Environmental and molecular mutagenesis (2019)
Mutations induced in somatic cells and germ cells are responsible for a variety of human diseases, and mutation per se has been considered an adverse health concern since the early part of the 20th Century. Although in vitro and in vivo somatic cell mutation data are most commonly used by regulatory agencies for hazard identification, that is, determining whether or not a substance is a potential mutagen and carcinogen, quantitative mutagenicity dose-response data are being used increasingly for risk assessments. Efforts are currently underway to both improve the measurement of mutations and to refine the computational methods used for evaluating mutation data. We recommend continuing the development of these approaches with the objective of establishing consensus regarding the value of including the quantitative analysis of mutation per se as a required endpoint for comprehensive assessments of toxicological risk. Environ. Mol. Mutagen. 61:34-41, 2020. © 2019 Wiley Periodicals, Inc.
Keyphrases
- induced apoptosis
- electronic health record
- cell cycle arrest
- decision making
- healthcare
- big data
- endothelial cells
- public health
- high resolution
- transcription factor
- stem cells
- signaling pathway
- emergency department
- mental health
- gene expression
- risk assessment
- health information
- cell proliferation
- climate change
- data analysis
- high glucose
- pi k akt
- mass spectrometry
- oxide nanoparticles
- pluripotent stem cells
- breast cancer risk