Escitalopram alters local expression of noncanonical stress-related neuropeptides in the rat brain via NPS receptor signaling.

Aneta Piwowarczyk-Nowak Artur Pałasz Aleksandra Suszka-Świtek Alessandra Della Vecchia Aniela Grajoszek Marek Krzystanek John J Worthington

Published in: Pharmacological reports : PR (2022)

The pharmacological effects of escitalopram may be connected with local NPSR-related alterations in NPS/NMU/NMUR2 and nesfatin-1 gene expression at the level of selected rat brain regions. A novel alternative mode of SSRI action can be therefore cautiously proposed.

Keyphrases

gene expression
major depressive disorder
poor prognosis
dna methylation
binding protein
oxide nanoparticles