Effect of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on Akt protein expression is more effective in head and neck cancer cell lineages that retain PTEN protein expression.

Flávia Sirotheau C PontesHelder Antonio Rebelo PontesLucas L de SouzaAdriana S de JesusAndrea M C JoaquimLigia A N MiyaharaFlávia Sirotheau Correa PontesDécio S Pinto Junior

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2018)

These data allow us to speculate on the particular utility of 17-AAG for HNSCC treatment through the inhibition of Akt protein expression, especially in the cases that retain the expression of PTEN protein.

Keyphrases

cell proliferation
signaling pathway
pi k akt
poor prognosis
binding protein
electronic health record
big data
long non coding rna
combination therapy
amino acid
replacement therapy
artificial intelligence
deep learning