Combined all-trans retinoic acid with low-dose apatinib in treatment of recurrent/metastatic head and neck adenoid cystic carcinoma: A single-center, secondary analysis of a phase II study.

Lulu YeLin ZhangRongrong LiXinhua PanJiang LiShengjin DouWen JiangChong WangWantao ChenGuo-Pei Zhu

Published in: Cancer medicine (2023)

All-trans retinoic acid combined with low-dose apatinib might be a potential efficacy therapeutic option for patients with R/M ACCHN. This finding will be further confirmed by our registered ongoing trial, the APLUS study (NCT04433169).

Keyphrases

low dose
phase ii study
high dose
open label
squamous cell carcinoma
small cell lung cancer
locally advanced
study protocol
clinical trial
randomized controlled trial
climate change
smoking cessation