Metformin has anti-inflammatory effects and induces immunometabolic reprogramming in hidradenitis suppurativa via multiple mechanisms.
Andreea PetrascaRoisin A HamblyNiamh KearneyConor M SmithEmily K PenderJulie Mac MahonAoife M O'RourkeMohamed IsmaielPatrick A BolandJose P AlmeidaCzara A KennedyAlexandra ZaborowskiSiun MurphyDesmond WinterBrian KirbyJean M FletcherPublished in: The British journal of dermatology (2023)
Our study provides insight into the mechanisms of action of metformin in HS. The anti-inflammatory effects of metformin support its use as a therapeutic agent in HS, while its effects on immunometabolism suggest that targeting metabolism is a promising therapeutic option in inflammatory diseases, including HS.