Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma.

Zijun Y Xu-MonetteLi WeiXiaosheng FangQingyan AuHarry NunnsMáté NagyAlexandar TzankovFeng ZhuChiara Rusconi Govind Bhagat Karen DybkærApril ChiuWayne TamYouli ZuEric D HsiFredrick B HagemeisterXiaoping SunXin HanHeounjeong GoMaurilio PonzoniAndrés J M FerreriMichael Boe Møller Benjamin M Parsons J Henricus van KriekenMiguel A PirisJane N WinterYong LiBing XuMaher AlbitarHua YouKen H Young

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Together, these results demonstrated independent and additive prognostic effects of phenotypic MYC/BCL2 and microenvironment biomarkers and genetic subtyping in DLBCL prognostication, important for improving DLBCL classification and identifying prognostic determinants and therapeutic targets.

Keyphrases

diffuse large b cell lymphoma
genome wide
epstein barr virus
stem cells
single cell
transcription factor
poor prognosis
machine learning
copy number
dna methylation
gene expression