Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease.
Marie FiskJoseph CheriyanDivya MohanCarmel M McEnieryJulia FormanJohn R CockcroftJames H F RuddRuth Tal-SingerNicholas S HopkinsonMichael I PolkeyIan B WilkinsonPublished in: Respiratory research (2018)
In this cross-sectional prospective study, novel findings were that both usual COPD and α1ATD-COPD patients have increased aortic inflammation and stiffness compared to smoking and never-smoking controls, regardless of smoking history. These findings suggest that the presence of COPD lung disease per se may be associated with adverse aortic wall changes, and aortic inflammation and stiffening are potential mechanisms mediating increased vascular risk observed in COPD patients.
Keyphrases
- chronic obstructive pulmonary disease
- end stage renal disease
- aortic valve
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- lung function
- left ventricular
- cross sectional
- pulmonary artery
- peritoneal dialysis
- prognostic factors
- smoking cessation
- emergency department
- patient reported outcomes
- aortic dissection
- climate change
- risk assessment
- atrial fibrillation
- pulmonary hypertension